The sphere of nanomaterials has progressed dramatically over the previous many years with necessary contributions to the biomedical space. The physicochemical properties of nanomaterials, comparable to measurement and construction, might be managed by manipulation of mass and warmth switch situations throughout synthesis. Specifically, microfluidic techniques with speedy mixing and exact fluid management are perfect platforms for creating applicable synthesis situations. One notable instance of microfluidics-based synthesis is the event of lipid nanoparticle (LNP)-based mRNA vaccines with accelerated medical translation and sturdy efficacy in the course of the COVID-19 pandemic. Along with LNP, microfluidic techniques have been adopted for the managed synthesis of a broad vary of nanomaterials. On this overview, we introduce the basic rules of microfluidic applied sciences together with move field- and a number of field-based strategies for fabricating nanoparticles, and focus on their purposes within the biomedical subject. We conclude this overview by outlining a number of main challenges and future instructions within the implementation of microfluidic synthesis of nanomaterials.