Rodan Gideon, A. & Martin, T. J. Therapeutic approaches to bone ailments. Science 289, 1508–1514 (2000).
Chaudhari, Okay. R. et al. Bone metastasis concentrating on: a novel method to succeed in bone utilizing Zoledronate anchored PLGA nanoparticle as provider system loaded with Docetaxel. J. Management. Launch 158, 470–478 (2012).
Tavassoli, M. The marrow–blood barrier. Br. J. Haematol. 41, 297–302 (1979).
Adjei, I. M., Sharma, B., Peetla, C. & Labhasetwar, V. Inhibition of bone loss with surface-modulated, drug-loaded nanoparticles in an intraosseous mannequin of prostate most cancers. J. Management. Launch 232, 83–92 (2016).
Solar, W. et al. Bone-targeted nanoplatform combining zoledronate and photothermal remedy to deal with breast most cancers bone metastasis. ACS Nano 13, 7556–7567 (2019).
Chen, Q. et al. Bone focused supply of SDF-1 by way of alendronate functionalized nanoparticles in guiding stem cell migration. ACS Appl. Mater. Interfaces 10, 23700–23710 (2018).
Mann, A. P. et al. E-selectin-targeted porous silicon particle for nanoparticle supply to the bone marrow. Adv. Mater. 23, H278–H282 (2011).
Wang, H. et al. Tetracycline-grafted PLGA nanoparticles as bone-targeting drug supply system. Int. J. Nanomed. 10, 5671–5685 (2015).
Aoki, Okay., Alles, N., Soysa, N. & Ohya, Okay. Peptide-based supply to bone. Adv. Drug Deliv. Rev. 64, 1220–1238 (2012).
Lavrador, P., Gaspar, V. M. & Mano, J. F. Stimuli-responsive nanocarriers for supply of bone therapeutics – limitations and progresses. J. Management. Launch 273, 51–67 (2018).
Lahoz-Beneytez, J. et al. Human neutrophil kinetics: modeling of steady isotope labeling knowledge helps quick blood neutrophil half-lives. Blood 127, 3431–3438 (2016).
Theilgaard-Mönch, Okay. et al. The transcriptional program of terminal granulocytic differentiation. Blood 105, 1785–1796 (2005).
Martin, C. et al. Chemokines performing by way of CXCR2 and CXCR4 management the discharge of neutrophils from the bone marrow and their return following senescence. Immunity 19, 583–593 (2003).
Cacalano, G. et al. Neutrophil and B cell growth in mice that lack the murine IL-8 receptor homolog. Science 265, 682–684 (1994).
Eash, Okay. J., Greenbaum, A. M., Gopalan, P. Okay. & Hyperlink, D. C. CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. J. Clin. Make investments. 120, 2423–2431 (2010).
Lawrence, S. M., Corriden, R. & Nizet, V. How neutrophils meet their finish. Tendencies Immunol. 41, 531–544 (2020).
Borregaard, N. Neutrophils, from marrow to microbes. Immunity 33, 657–670 (2010).
Wang, J. et al. Visualizing the perform and destiny of neutrophils in sterile damage and restore. Science 358, 111–116 (2017).
Garner, H. & de Visser, Okay. E. Neutrophils take a round-trip. Science 358, 42–43 (2017).
Furze, R. C. & Rankin, S. M. Neutrophil mobilization and clearance within the bone marrow. Immunology 125, 281–288 (2008).
Suratt, B. T. et al. Neutrophil maturation and activation decide anatomic web site of clearance from circulation. Am. J. Physiol. Lung Cell. Mol. Physiol. 281, L913–L921 (2001).
Løvås, Okay., Knudsen, E., Iversen, P. O. & Benestad, H. B. Sequestration patterns of transfused rat neutrophilic granulocytes underneath regular and inflammatory circumstances. Eur. J. Haematol. 56, 221–229 (1996).
Hofman, M. S. et al. 177Lu-PSMA-617 versus cabazitaxel in sufferers with metastatic castration-resistant prostate most cancers (TheraP): a randomised, open-label, section 2 trial. Lancet 397, 797–804 (2021).
Wang, J. et al. ROS-responsive nanocomplex of aPD-L1 and cabazitaxel improves intratumor supply and potentiates radiation-mediated antitumor immunity. Nano Lett. 22, 8312–8320 (2022).
Blick, S. Okay. A., Dhillon, S. & Keam, S. J. Teriparatide. Medication 68, 2709–2737 (2008).
Xue, J. et al. Neutrophil-mediated anticancer drug supply for suppression of postoperative malignant glioma recurrence. Nat. Nanotechnol. 12, 692–700 (2017).
Schwartz, R. S. & Erban, J. Okay. Timing of metastasis in breast most cancers. N. Engl. J. Med. 376, 2486–2488 (2017).
Cai, W.-L. et al. microRNA-124 inhibits bone metastasis of breast most cancers by repressing Interleukin-11. Mol. Most cancers 17, 9 (2018).
Taguchi, T. SY7-2 – therapy technique of bone metastasis in breast most cancers. Ann. Oncol. 28, ix33 (2017).
Parveen, S. et al. Therapeutic concentrating on with DABIL-4 depletes myeloid suppressor cells in 4T1 triple-negative breast most cancers mannequin. Mol. Oncol. 15, 1330–1344 (2021).
Balog, J. et al. Single cell mass cytometry revealed the immunomodulatory impact of cisplatin by way of downregulation of splenic CD44+, IL-17A+ MDSCs and promotion of circulating IFN-γ myeloid cells within the 4T1 metastatic breast most cancers mannequin. Int. J. Mol. Sci. 21, 170 (2019).
DuPre, S. A. & Hunter, Okay. W. Jr Murine mammary carcinoma 4T1 induces a leukemoid response with splenomegaly: affiliation with tumor-derived progress elements. Exp. Mol. Pathol. 82, 12–24 (2007).
Yun, H. M. et al. 2,4,5-Trimethoxyldalbergiquinol promotes osteoblastic differentiation and mineralization by way of the BMP and Wnt/β-catenin pathway. Cell Loss of life Dis. 6, e1819 (2015).
Al Rifai, O. et al. Proprotein convertase furin regulates osteocalcin and bone endocrine perform. J. Clin. Make investments. 127, 4104–4117 (2017).
Yeom, J., Ma, S. & Lim, Y.-H. Probiotic Propionibacterium freudenreichii MJ2 enhances osteoblast differentiation and mineralization by growing the OPG/RANKL ratio. Microorganisms 9, 673 (2021).
An, J. M. et al. Oral supply of parathyroid hormone utilizing a triple-padlock nanocarrier for osteoporosis by way of an enterohepatic circulation pathway. ACS Appl. Mater. Interfaces 13, 23314–23327 (2021).
Bain, B. J. & England, J. M. Regular haematological values: intercourse distinction in neutrophil depend. Br. Med. J. 1, 306–309 (1975).
Wright, L. E. et al. Murine fashions of breast most cancers bone metastasis. Bonekey Rep. 5, 804–804 (2016).